IDH1 and glioblastoma: Furthermore, within the updated classification, IDH wild-type diffuse astrocytic tumors in adults, which lack the typical histological features of glioblastoma but exhibit any of three specific genetic parameters (TERT promoter mutation, EGFR gene amplification, or the combined gain of the entire chromosome 7 and the loss of the entire chromosome 10 [+7/−10]), also fall under the category of glioblastomas.