Dando et al. reported that the inhibition of mitochondrial uncoupling protein 2 (UCP2) protein induces the ROS generation and in turn nuclear translocation GA3PDH, inactivation of Akt/mTOR/P70S6K signaling pathway promoting the apoptosis independent of caspases and autophagy mediated by Beclin1 in pancreatic adenocarcinoma cells [206]. This evidence concerns the gene UCP2 and pancreatic adenocarcinoma.