Moreover, GBM has been classified into four molecular types: classical characterized by EGFR amplification and CDNM2A deletion, mesenchymal (mesenchymal markers with NF1 deletion), proneural (PDGFRA amplification and isocitrate dehydrogenase 1 (IDH) mutation), and neural (neuronal markers) [248]. Here, IDH1 is linked to glioblastoma.