AKT1 and central nervous system cancer: Simvastatin a hydroxymethylglutaryl-coenzyme A reductase (HMG-CoAR) inhibitor promotes cell death in C6 and U251 glioma by inducing the AMPK, LC3-II Beclin1 activation, inactivation of AKT and in turn mTOR/p70 S6 kinase1, also down the mevalonate levels [221].