On the other hand, it has been described that the glycolytic pathway modulates apoptosis via PMK2, GA3PDH, and HK2 [162] (Figure 2 and Figure 3), whereas HK2 and PMK2 inhibit the apoptosis in cancer cells to confer cellular protection under starvation conditions such as glucose and glutamine promoting the migration and high resistance to therapies [163,164]. Here, HK2 is linked to cancer.