PKM and central nervous system cancer: PKM2 also acts as a protein kinase; after the activation of EGF/EGFR, PMK2 is translocated to the nucleus and binds and phosphorylates at Thr11 histone H3 inducing the release of Histone Deacetylase (HDAC) 3 from histone H3 with the subsequent acetylation at Lys9 histone H3 and genic expression of c-myc and cyclin D1, which promotes the cell proliferation and tumorigenesis of glioma cells [143].