The silencing of GS decreased GBM cell line proliferation and colony formation both in the presence and absence of glutamine [304], whereas in another study the silencing GS potentiated rat C6 glioma cell motility [310] supplying NADH and amide group for fatty acid, sugars nucleotides synthesis, required in highly proliferative cells such as gliomas [267,301,311,312]. The gene discussed is GLUL; the disease is central nervous system cancer.