On the other hand, it has been demonstrated that the RSL3 compound induces dysfunction in the glycolysis, which promotes autophagic cell death through inactivation in the HK2, PFK, and PKM2 enzymatic activities and increases autophagic markers such as pAMPK, pULK1, Beclin 1, Atg5,-12, and LC3II in human glioma cells as U251, U87, and U373, as well as xenograft glioma in vivo model. Here, HK2 is linked to central nervous system cancer.