AKT1 and central nervous system cancer: The overexpression of WW domain-binding protein 2 (WBP2) also has been detected in glioma; moreover, WBP2 was associated with the binding to α-enolase protein (codified by ENO1), which was associated with cell proliferation and migration, along with an increase in the glycolytic activity through ENO1/PI3K/AKT pathway [132].