PKM and central nervous system cancer: In this sense, also it has been suggested that the phosphorylation in Tyr105 PKM2, induced by the chemokine receptor US28, promotes the translocation of nuclear PKM2 which acts as a transcriptional coactivator of HIF-1 and STAT3 transcription factors enhancing the metabolic reprogramming, cell proliferation, and angiogenesis in glioma cells [146].