To explore the critical role of disulfidptosis in cancer and the interactions between disulfide apoptosis and lncRNAs, we identified and validated a set of key lncRNAs associated with disulfidptosis in HCC, including PLBD1-AS1, GASAL1, AC128687.2, MKLN1-AS, AC026412.3, and LINC01269. Here, PLBD1 is linked to hepatocellular carcinoma.