MMP9 and neoplasm: Investigation on human GB patients demonstrated expression of proteases ADAM8, 10, and 17, and MMP9 and 14, which are associated with the occurrence of GAMs and support their functions, e.g., shedding of EGF-R by ADAM17 can direct cancer cell invasion [64], ADAM10 can regulate macrophage survival [65], whereas ADAM8 in macrophages increases MMP9 levels in co-cultured tumor cells [66] so that these ADAM proteases are associated with GAM functions and directly affect the nature of the TME [67,68].