Given the fact that the experiments on siRNA- or shRNA-mediated knockdown are typically carried out in order to investigate the tumor-suppressing role of GAS5 in varying cancer types and result in the partial downregulation of GAS5 lncRNA (to the levels comparable with those in cell lines “74-4” and 74-81-8) we briefly compared the strategies and the effects detected. Here, GAS5 is linked to neoplasm.