In addition, according to the studies, the upregulation of WNT4 under the influence of platelet-derived growth factor-BB (PDGF-BB) promotes VSMC proliferation through the frizzled-1 receptor and β-catenin, which explains the close correlation between WNT4 and the progression of stenosing atherosclerosis [43,44]. The gene discussed is WNT4; the disease is atherosclerosis.