NFKB1 and type 2 diabetes mellitus: Furthermore, it has been suggested that the generation of ROS through hyperglycaemia triggers several stress-sensitive signaling pathways, such as p-38 mitogen-activated protein kinases (MAPK), nuclear factor kappa B (NF-κB) and Jun amino-terminal kinases/stress-activated protein kinases (JNK/SAPK), which in turn accelerates the development of complications related to T2DM [27].