Wu et al. identified amplification of 11q22.2 as prevailing copy-number alterations associated with strong overexpression of the YAP1, BIRC2, and BIRC3 cancer-related genes in head-and-neck squamous cell carcinomas (HNSCCs) in patients with Fanconi anemia. The gene discussed is BIRC3; the disease is Fanconi anemia.