Wu et al. identified amplification of 11q22.2 as prevailing copy-number alterations associated with strong overexpression of the YAP1, BIRC2, and BIRC3 cancer-related genes in head-and-neck squamous cell carcinomas (HNSCCs) in patients with Fanconi anemia. This evidence concerns the gene BIRC3 and head and neck squamous cell carcinoma.