On the other hand, HADH deficiency known by clinicians as short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) deficiency (OMIM#231530) is a fatty acid oxidation disorder causing hyperinsulinism in pediatric patients [46], unrelated to 17β-HSD10 indeed even if both could catalyze the oxidation of acyl-CoA derivatives in mitochondria to provide energy. Here, HSD17B10 is linked to hyperinsulinemic hypoglycemia, familial, 4.