PKCα overexpression has been implicated in the pathogenesis of hypertension [251,252,253], and an increased level of PKCβ was also demonstrated in a rat model of hypertension-induced cardiac dysfunction by a high-salt diet [254], which was consistent with the analysis of human tissue from heart-failure patients [67,215,216,255]. The gene discussed is PRKCB; the disease is hypertensive disorder.