Precise control of PKC signal amplitude is necessary for the healthy condition of a cell and an organism, and the alteration of normal PKC activity is linked to numerous human diseases, including metabolic disorders [55,56], neurodegenerative disease [2], autoimmune disease [57,58,59,60], cancer [61], and CVDs [62,63,64]. Here, PRRT2 is linked to neurodegenerative disease.