For example, PKCδ acts as an antiapoptotic regulator in chronic lymphocytic leukemia (CLL) [157] and as a proapoptotic factor in acute myeloid leukemia (AML) [158], and PKCα shows proliferative functions in several types of cancer [159] but has antiproliferative functions in colon cancer cells [160]. The gene discussed is PRKCA; the disease is B-cell chronic lymphocytic leukemia.