ACN reduced the expression of MID1IP1 and c-Myc; simultaneously, the loss of L5 and L11 reversed the expression of c-Myc reduction to ACN in HCT116p53+/+ and HCT116p53−/−, which showed the least expression of c-Myc at 25 μM in four CRC cell lines (Figure 5D,E). This evidence concerns the gene MID1IP1 and colorectal carcinoma.