APP and Alzheimer disease: In these terms, the observed role of the persistent neuronal inflammation in the predisposition to AD could be due to its contribution to the elicitation of the integrated stress response in neuronal cells and, consequently, to the facilitation of activation of the AβPP-independent iAβ production pathway even if the levels of AβPP-derived iAβ are below the critical ISR-triggering threshold (further discussed in Section 17.3).