However, the lifespan of APC-like neutrophils may be extended in naïve tissues and in the presence of cytokines like TNF-α and GM-CSF, for instance, in the synovium of inflamed joints affected by rheumatoid arthritis or in the TME, which may allow antigen presentation to co-localizing naïve CD4+ T cells [8,44,81,90]. This evidence concerns the gene CD4 and rheumatoid arthritis.