Salient features of severe COVID-19 include an elevated neutrophil-to-lymphocyte ratio [194], the emergence of immature neutrophil populations in both the blood and lungs [195,196,197], and activated pro-inflammatory neutrophil phenotypes in both the circulation and lungs with an enhanced production of TNF-α, IL-6, CXCL8, alarmins like calprotectin (SA100A8/A9), and NETs [198,199,200]. Here, TNF is linked to COVID-19.