In COVID-19, neutrophils contribute to disease pathogenesis by producing pro-inflammatory cytokines like TNF-α and IL-6 that contribute to lung-centric and systemic cytokine storms and the chemokine CXCL8 to promote further neutrophil recruitment and augment inflammation [114,115,116,117,118,119]. The gene discussed is CXCL8; the disease is COVID-19.