Indeed, Cu depletion in a tumor cell line inhibited the cellular characteristics of hypoxia-induced EMT by downregulating the expression of vimentin and fibronectin genes, which are under the control of the HIF1-α/Snail/Twist signaling pathway, and Cu depletion also inhibited angiogenesis in a mouse model [107]. The gene discussed is HIF1A; the disease is neoplasm.