Topical application of CLA significantly inhibited pro-inflammatory cytokines, including interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)-α, and the expression of the pro-inflammatory enzymes inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse dermatitis [63]. This evidence concerns the gene PTGS2 and skin disorder.