After the transfer of CD4+CD45RBHigh T cells into severe combined immunodeficiency (SCID) mice, treatment with a neutralizing anti-NKG2D MAb significantly inhibited marasmus associated with colitis, alleviated leukocyte infiltration, and reduced IFN-γ production by CD4+ T cells in the membranes propria. This evidence concerns the gene CD4 and marasmus.