Hosomi found that the deletion of the X-box binding protein 1 (Xbp1) gene in intestinal epithelial cells led to the increased expression of ULBP and spontaneous enteritis in mice, while blocking NKG2D inhibited the cytolysis of endoplasmic reticulum (ER) pressurized epithelial cells in vitro and spontaneous enteritis in vivo [113,114]. This evidence concerns the gene KLRK1 and enteritis.