KLRK1 and systemic lupus erythematosus: In the study by Dai et al. in adolescent SLE patients, increased frequencies of soluble MICA (sMICA), soluble MICB (sMICB), and interleukin-10 (IL-10)-producing NKG2D+CD4+ T cells were observed and were negatively correlated with the severity of SLE [46].