CD4 and experimental autoimmune encephalomyelitis: In experimental autoimmune encephalomyelitis (EAE) animal models, the blocking of NKG2D inhibited the migration of NKG2D+CD4+ T cells to the CNS and weakened the killing effect on mouse oligodendrocytes, suggesting that NKG2D promoted the migration of NKG2D+CD4+ T cells across the blood–brain barrier [78].