miR-205 is downregulated in pancreatic cancer and, in an in vitro model, the overexpression of miR-205 decreased the expression of both general stemness markers such as OCT-3/4 and NANOG, and more specific pancreatic CSC markers such as CD44 and ALDH1 [90]. This evidence concerns the gene POU5F1 and familial pancreatic carcinoma.