miR-205 is downregulated in pancreatic cancer and, in an in vitro model, the overexpression of miR-205 decreased the expression of both general stemness markers such as OCT-3/4 and NANOG, and more specific pancreatic CSC markers such as CD44 and ALDH1 [90]. The gene discussed is NANOG; the disease is familial pancreatic carcinoma.