The underexpression or loss of expression of these miRNAs plays a substantial role in the progression of the disease by impacting multiple signaling pathways, such as AK4P1/SP1, c-MYC/SIRT1, the Wnt/β-catenin pathway, and the DLEU2/SMAD2 pathway, that lead to cancer cell proliferation, invasion, metabolism, and immune responses [53,54,55,56,57]. Here, SMAD2 is linked to cancer.