The intravenous infusion of human CD166.Bζ-CAR T cells to immunodeficient mice (NOD/SCID) challenged with human osteosarcoma cells showed increased tumour infiltration, suppression of tumour growth, and lack of morphological changes in different organs (lung, heart, liver, spleen, intestine, and kidney) compared with non-transduced T cells and non-treated controls [59]. Here, ALCAM is linked to osteosarcoma.