Recent experiments in which human CD166/ALCAM- and/or CD318/CDCP1-positive cancer cell lines of different origins (i.e., breast, lung, and prostate) were co-cultured with human peripheral blood mononuclear cells (PBMCs) in the presence of the UMCD6 (anti-human CD6) or 3a11 (anti-human CD318) mAbs have rendered interesting, though somehow unexpected, results [56]. The gene discussed is CD6; the disease is cancer.