CD6 and neoplasm: Mechanistically, the authors demonstrated that following UMCD6 mAb-induced CD6 internalisation in T and NK cells, a downregulated expression of the inhibitory NKG2A receptor and an upregulated expression of the activating NKG2D receptor, as well as of perforin and granzyme B, is observed in both NK and CD8+ T cells, thus resulting in increased anti-tumour cytotoxic capabilities (Figure 2B, left-hand side).