Unpublished preliminary in vitro observations made by our group using human leukemic NK cell-derived KHYG-1 cells stably transduced with a second-generation CD6-CAR also show superior cytotoxic activity against high CD166/ALCAM-expressing human cancer cell lines from colon (DLD-1) and ovary (SKOV-3) origin, compared to the control non-transduced cells. The gene discussed is ALCAM; the disease is cancer.