It is known that the enzyme NAD(P)H:quinone oxidoreductase (NQO1) is predominantly required for apoptotic or necrotic cell death induced by β-Lap in various cancer cell types through the modulation of DNA damage, caspase-3, PARP1, PI3K/AKT signaling, NF-κB, telomerase reverse transcriptase (TERT), DNA topoisomerase I and II, and CD44 [15,16,17,18,19,20,21,22,23]. The gene discussed is NQO1; the disease is cancer.