TP53 and retinoblastoma: Notably, β-Lap treatment alone induced cell cycle arrest and apoptosis in human leukemia, prostate, and colon cancer cells in a p53-independent manner [25,26], and the combined treatment of β-Lap and paclitaxel was shown to induce synergistic apoptosis in human retinoblastoma Y79 cells through the downregulation of phospho-AKT levels and upregulation of p53 [27].