Creatinine, a plasma marker of kidney injury, was significantly higher in SAA-TKO mice (1.53 ± 0.07 mg/dL) than WT mice (1.006 ± 0.11 mg/dL) 24 h following CLP (Figure 4A), implying increased sepsis-induced kidney damage in SAA-TKO mice. This evidence concerns the gene SAA1 and Sepsis.