SAA1 and Sepsis: Consistently, SAA-TKO mice showed decreased lung compliance (0.049 ± 0.005 mL/cmH2O) compared to WT mice (0.067 ± 0.002 mL/cmH2O) (Figure 4D) and a trend for decreased inspiratory capacity (Figure 4E), 24 h after sepsis induction by CS treatment.