Therefore, it is important to simultaneously examine colitis models induced by trinitrobenzene sulfonic acid, which injures the mucosal barrier and acts as a hapten for the gut microbiota, causing Th1-dependent immune activation and infiltration of CD4+ T cells into the intestinal mucosa, or oxazolone, which causes Th2 cell responses, in order to provide more insight into the immunomodulatory potential and efficacy of immortalized cADSCs [90]. Here, CD4 is linked to colitis.