Immune cells release inflammatory cytokines such as interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 17 (IL-17), interferons (INF), chemokine 8 (CXCL8), chemokine 9 (CXCL9), and chemokine 10 (CXCL10), as well as the induction of the expression of adhesion proteins such as P-selectin (P-sel), E-selectin (E-sel), intercellular adhesion molecule-1 (ICAM-1,) and vascular cell adhesion molecule-1 (VCAM-1), which are associated with the inflammatory process to which the persistence of symptomatology observed in LC is related [14,15,16]. The gene discussed is SELE; the disease is laryngotracheoesophageal cleft.