Patients with acute deterioration of liver cirrhosis and non-HRS renal dysfunction and inflammation with coexisting tubular damage have higher values of urinary TLR4, which suggests a potential role of TLR4 in renal injury pathophysiology and indicates the potential role of ATN-AKI as a biomarker [70]. Here, TLR4 is linked to oculocutaneous albinism type 1.