Accumulation of Aβ and tau proteins, as well as other metabolic waste, due to compromised glymphatic clearance mechanisms, is thought to contribute to the pathogenesis and progression of Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), multiple sclerosis (MS), among others [9]. The gene discussed is MAPT; the disease is amyotrophic lateral sclerosis.