IL1RAP and obesity due to melanocortin 4 receptor deficiency: Specifically, intercept effects were detected for DVL2 (p = 0.017) and ETS1 (p = 0.011); a tissue effect was detected for IL1RAP; an interaction effect was observed between tissue depot, obesity, and sex for DVL2 (p = 0.019); an interaction effect was observed between obesity and sex for ETS1 (p = 0.025); and an interaction effect was detected between tissue, diabetes, and sex for DVL2 (p = 0.025) (Figure 4A).