IL1RAP and obesity due to melanocortin 4 receptor deficiency: In conclusion, our findings underscore a prospective trajectory for future investigations, elucidating the intricate interplay between obesity, T2D, the miR-221-3p/222-3p cluster, and their target genes (ETS1, DVL2, and IL1RAP) in the modulation of AT functionality in the context of both T2D and obesity.