Gaens et al. conducted a study on subcutaneous tissues—obtained from 10 patients with grade I/II obesity (mean BMI 34.2 ± 4.0 kg/m2) and from 9 normal weight controls—and found that AGER expression in both mRNA and protein levels is higher in the course of obesity [21]. This evidence concerns the gene AGER and obesity due to melanocortin 4 receptor deficiency.