In another PAH rat model induced by monocrotaline and pneumonectomy, administration of resorcinolnaphthalein improved hemodynamics, pathological changes, and endothelial dysfunction, all of which were associated with an increase in the levels of ACE2 and Ang-(1-7) and a decrease in the levels of ACE and Ang II. This evidence concerns the gene ANG and pulmonary arterial hypertension.