ANG and pulmonary arterial hypertension: With the use of a rat model which overexpressed Ang-(1-7), Gomes et al. [25] evaluated the potential downstream pathways associated with Ang-(1-7)-mediated cardioprotection in PAH and found that Ang-(1-7) utilizes a nitric oxide/guanosine 3′,5′-cyclic monophosphate-dependent pathway to prevent cardiomyocyte hypertrophy [25].