Recently, it has been demonstrated in vivo and in vitro how the endogenous peptide adrenomedullin serum level increases in production and expression during severe infection, because it is an efficient counter-regulatory molecule with the purpose of the regulation and stabilization of the endothelial barrier and the protection of the microcirculation and then of the hemodynamic balance [50,51,52,53]. The gene discussed is ADM; the disease is infection.