In the last years, it has been shown that RECK regulates other members of the MMP family such as MMP-2, MMP-7, a matrilysin implicated in cardiac remodeling [3], MMP-17 or MT4-MMP that belongs to the membrane-type matrix metalloproteinases (MT-MMPs), anchored to the cell surface by a glycosylphosphatidylinositol (GPI) motif, whose expression is well documented in a variety of cancers [4]. This evidence concerns the gene RECK and cancer.