MMP9 and hepatocellular carcinoma: A recent study reported that mortalin, an oncogene, played a role in the migration and invasion of HCC cells through the regulation of RECK/STAT3 pathway; salvianolic acid B, a caffeic acid phenethyl ester analog, was able to increase the degradation of mortalin through ubiquitination, thereby upregulating RECK with a downregulation of MMP-2 and MMP-9, inhibiting STAT3, and inhibiting the migration and invasion of HCC cells [73].