In addition, CD133 is detected in many malignant tumors, such as prostate [24], lung [25,26], ovarian [27], breast [28], endometrial [29], renal [30], thyroid [31], esophageal [32], gastric [33,34], colorectal [35], pancreatic [1], hepatocellular [36,37], and gallbladder [38] carcinoma, as well as in glioma [39], meningioma [40], osteosarcoma [41], melanoma [42], cutaneous squamous cell carcinoma [43], and other solid malignant neoplasms. This evidence concerns the gene PROM1 and osteosarcoma.