Following this logic, we designed the PSMA ligand BQ0413, which contains 2-napththyl-L-alanine and L-tyrosine in the linker to improve binding to PSMA and the mercaptoacetyl–triglutamate chelator (maEEE) for labeling with Tc-99m for the diagnostic imaging of PCa using SPECT (Figure 1C). Here, FOLH1 is linked to posterior cortical atrophy.