GPX1 and Hyperglycemia: In addition, hyperglycaemia and dyslipidaemia perturbs renal antioxidant capacity by lowering glutathione (GSH), glutathione peroxidase-1 (GPx1), superoxide dismutase-1 (SOD1), and catalase (CAT) that subsequently induce lipid peroxidation, protein damage, and chronic inflammation [5,6,7].