The mechanisms underlying accelerated neurodegeneration in females is unknown but could be due to the sex-selective vulnerability of specific brain regions that have reciprocal connections to other regions [45,46], the interactions between tau pathology and sex-specific genes, chromosomes, and/or hormones [47], possible genetic modifying factors [28], and the sex-specific amyloid and/or tau dynamics. This evidence concerns the gene MAPT and amyloidosis.