The comparison of SLE patients with and without different organ involvement, and with different severities of organ manifestations, showed elevated serum sTfR levels in SLE patients with myocardial infarction (p = 0.003), ischemic heart disease (p = 0.03), lung involvement (p = 0.02), and hematological manifestations (p = 0.002). The gene discussed is TFRC; the disease is systemic lupus erythematosus.