Inclusion criteria were: human (clinically relevant) studies of any study design (at least 10 patients per study); English papers; the following combination of key words within the title and/or abstract: “aldosterone” AND “bone”, “skeleton”, “osteoporosis”, “fracture”, “calcium”, “parathyroid”, “DXA”, “osteocalcin”, “P1NP”, “alkaline phosphatase”, “bone marker”, “trabecular bone score” or “FRAX”. The gene discussed is BGLAP; the disease is osteoporosis.