However, there are also reports that CCL5 in GCF is not significantly different between patients with periodontitis—including aggressive periodontitis and severe forms of chronic periodontitis [49,50]—and healthy subjects; between sites affected by generalized periodontitis and healthy sites [51]; and between rheumatoid arthritis patients with periodontitis compared to those without periodontitis [52]. The gene discussed is CCL5; the disease is rheumatoid arthritis.