The interaction between TGF-β receptor type II (TβRII) and epithelial membrane protein 3 (EMP3) plays a critical role in the TGF-β1-mediated induction of the EMT and stem-like properties, as evidenced by the reduced migratory ability and resistance to irradiation in EMP3 knockdown A549 cells and the positive correlation between high EMP3 levels and poor survival rates in patients with NSCLC [109]. The gene discussed is EMP3; the disease is non-small cell lung carcinoma.