JAK1 and non-small cell lung carcinoma: M2 macrophage-derived IL-10 has been shown to induce stemness in A549 and H460 NSCLC cell lines via the JAK1/STAT1/NF-κB/Notch1 pathway [110], and IL-10 expression by TAMs correlates closely with the NSCLC stage and survival of NSCLC patients [110,118].