STAT3 and lung carcinoma: In an independent study by scientists from Tianjin Medical University General Hospital, the EMT-stimulating effect of IL6 produced by CAFs was shown to be based on the activation of the JAK2/STAT3 signaling pathway: it was found that the pretreatment of lung cancer cells with JAK2- and STAT3-specific inhibitors, AG490 and Stattic, respectively, significantly reversed the effect of the CAF-conditioned medium on the regulation of EMT- and metastasis-related genes and cell motility [38].