AKT1 and melanoma: Of note, Fogli et al. [37] documented that oleocanthal (at a concentration of 10 μM) exhibits a remarkable and selective in vitro antiproliferative activity against human melanoma cells (A375 and 501Mel cell lines), an effect that was accompanied by the inhibition of extracellular signal-regulated kinase 1/2 (ERK 1/2) and AKT (Protein kinase B) phosphorylation, and by the downregulation of the anti-apoptotic protein Bcl-2 (B-cell lymphoma 2) expression.