MAPT and early-onset autosomal dominant Alzheimer disease: Microglia and astrocytes also play an important role in the pathophysiology of Alzheimer’s disease, as these cells become activated around the Aβ plaques and neurofibrillary tangles in the brain and drive neuroinflammatory responses that, in turn, exacerbate the neurodegeneration and further increase the Aβ and tau overproduction, thus triggering a vicious cycle [62,63].