Finally, a study conducted by Abdallah et al. [80] in homozygous 5xFAD mice (a preclinical model of Alzheimer’s disease characterized by an accelerated formation of amyloid plaques) demonstrated that a 3-month oleocanthal-enriched diet (with oleocanthal added at a dose of 0.5 mg/kg/day) decreased the brain Aβ levels and the neuroinflammation by suppressing the nuclear factor-κB (NF-κB) pathway and reducing the activation of the NLRP3 inflammasome. The gene discussed is NFKB1; the disease is early-onset autosomal dominant Alzheimer disease.