Alzheimer’s disease is one of the most common neurodegenerative disorders [58] and is pathologically defined by the accumulation of fibrillar amyloid beta (Aβ) peptide in extracellular amyloid plaques and by the abnormal deposition of tau filaments in the form of intracellular neurofibrillary tangles [59]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.