After adjusting for age, sex, previous MI, angina, HF, coronary artery disease, and left ventricular ejection fraction, cTnI/99th percentile ratio treated as a continuous variable emerged as an independent factor associated with higher mortality risk, with an HR (95% CI) of 1.08 (1.03–1.13, p = 0.001). The gene discussed is TNNI3; the disease is myocardial infarction.