Additionally, the impairments in the system responsible for antigen processing and presentation; the upregulation of constitutive PD-L1; the absence of tumor-specific antigens and antigenic mutations; perturbations in the signaling pathways; the genetic exclusion of T cells; and the modifications in immune evasion mechanisms may significantly contribute to the evasion of immune responses, as elucidated by Sharma et al. in their comprehensive review [62]. Here, CD274 is linked to neoplasm.