Some studies highlighted a correlation between ACSL4 expression and cancer aggressiveness and proliferation [89,90,91]; subjects with colorectal cancer with a high expression of ACSL4 have a poor prognosis and lower survival rate, while subjects with brain, breast, or lung cancer with lower ACSL4 expression have a more hopeful prognosis [91]. The gene discussed is ACSL4; the disease is colorectal cancer.