Interferon gamma (IFN-γ) released by CD8 T cells can hinder the uptake of cystine by tumor cells as it results in under regulation of the expression of SLC3A2 and SLC7A11 (subunits of the system Xc−) and thus induces lipid peroxidation and ferroptosis in ovarian carcinoma, melanoma, and fibrosarcoma [5,92]. This evidence concerns the gene IFNG and melanoma.