FLG and granular corneal dystrophy type II: With filaggrin being the most powerful humectant among barrier proteins [23], our study proposes that the moisturizing effect of oat sprouts originates from the increased filaggrin expressed by its unique steroidal saponin, avenacoside B. Moreover, oat sprouts can be used as a therapeutic reagent for ACD and other diseases such as atopic dermatitis or asthma, which are characterized by a disrupted skin barrier.