S1PR2 and hereditary elliptocytosis: McMillin et al. [26,27] reported that neuronal CCL2 is upregulated and contributes to microglia activation and neurological decline in mice with HE induced by azoxymethane [26] and that enhanced activation of the sphingosine-1-phosphate receptor 2 (S1PR2) promotes neuroinflammation in the cerebral cortex of these mice [27,28,29,30].