The use of a methylene blue-based photosensitizer (MB—Sigma-Aldrich, Riyadh, Saudi Arabia) and, subsequently, a HELBO® TheraLite–diode laser (Bredent Medical, Senden, Germany) within the periodontal pockets in addition to SRP significantly decreased the levels of IL-6 and TNF-α in patients with RA and periodontitis at 6-weeks more than SCR alone [125]. Here, TNF is linked to periodontitis.