Recently, vicenin-2, a major component of U. circularis, was found to hinder the production of inflammatory mediators such as tumor necrosis factor-α (TNF-α) and nitric oxide (NO) by inhibiting nuclear factor-kB (NF-kB), demonstrating the anti-inflammatory activity in the carrageen-induced rat paw edema model [15]. This evidence concerns the gene TNF and edema.