The aggregates formed in these diseases contain proteins such as TDP-43 (trans-activation response DNA-binding protein 43), FUS (fused in sarcoma), SOD1 (superoxide dismutase), and C9orf72 that are well-known pathologic hallmarks of ALS/FTLD [109,110,111,112,113,114,115,116]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.