In 14 out of 15 types of cancer including breast cancer, colon cancer, large intestine cancer, liver cancer, and skin cancer (melanoma), the higher the expression level of Nanog (NANOG), the higher the malignancy of the cancer cells (in vitro proliferation ability, migration ability, invasion ability, drug resistance, and in vivo metastatic ability). The gene discussed is NANOG; the disease is skin cancer.