This process is regulated by transcription factors in tumor cells (Snail 1, Slug, ZEB1, Twist, FOXC2, etc.)and signaling pathways from the tumor microenvironment (WNT, Notch, Hedgehog, TGFβ, FGF, EGF, HGF signaling, etc.). This evidence concerns the gene TGFB1 and neoplasm.