CKAP4 and obesity due to melanocortin 4 receptor deficiency: The top 20 pathways mapped with the DEPs are shown in Figure 4B. We found that 8 proteins (cytoskeleton associated protein 4, DnaJ heat shock protein family member C10, Oryctolagus cuniculus signal sequence receptor subunit 4 (SSR4), lectin mannose binding 1, SEC61 translocon alpha 1 subunit, ENSOCUP00000036470.1, ENSOCUP00000041431.1, ENSOCUP00000048909.1) were enriched in autophagy-related pathways, which may be associated with inflammation caused by obesity.