Despite the great variety of models, most of them share common genetic alterations that are able to induce human liver cancer, some of the most relevant: oncogenes (MYC, MET, RAS, NICD1, ERB2, NOTCH, AKT), tumor suppressors (P53, PTEN, FBXW7), and the WNT pathway (CTNNB1) [236]. Here, PTEN is linked to liver cancer.