The cross-talk between hepatocytes and other cell populations, constituents of the liver microenvironment, such as hepatic stellate cells (HSCs), liver sinusoidal endothelial cells (LSECs), liver-resident macrophages Kupffer cells, KCs), other immune cells, and hepatic progenitor cells (HPCs), is involved in hepatocarcinogenesis in the context of CLD, and in metastasis generation in later stages [1,18]. Here, TBCE is linked to congenital secretory chloride diarrhea 1.