Interestingly, regulators of EGFR signaling have been described as altered, e.g., ERBB receptor feedback inhibitor 1 (ERRFI1), a negative regulator of EGFR that inhibits its catalytic activity and mediates its lysosomal degradation, is frequently deleted in HCC (Cancer Genome Atlas Research Network, 2017) [180]. Here, EGFR is linked to hepatocellular carcinoma.