Their recruitment to the liver during HCC development and progression is mainly promoted by cytokines (e.g., granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), and IL-6) and chemokines, such as CCL2, according to data derived from different murine models of HCC [75]. This evidence concerns the gene CSF3 and hepatocellular carcinoma.