In the classic model, once liver cancer is generated, HSC activation in the peritumoral tissue contributes to HCC progression [20,36] through the secretion of growth factors, cytokines and chemokines such as VEGF, HGF, TGF-β1, PDGF, IL-6 and CX3CL1. The gene discussed is HGF; the disease is hepatocellular carcinoma.